Search
mitogen-activated protein kinase kinase kinase 2 (MAP3K2, MAPK/ERK kinase kinase 2, MEKK2, MAPKKK2)
Function:
- component of a protein kinase signal transduction cascade
- regulates the JNK & ERK5 pathways by phosphorylating & activating MAP2K5 & MAP2K7 (putative)
- plays a role in caveolae kiss-&-run dynamics
- binds both upstream activators & downstream substrates in multimolecular complexes
- activated by phosphorylation on Thr-524
- autophosphorylated (putative)
ATP + a protein ADP + a phosphoprotein
Cofactor: Mg+2
Structure:
- belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase kinase subfamily contains 1 OPR domain
- contains 1 protein kinase domain
Compartment:
- cytoplasm
- upon EGF stimulation, translocates into the nucleus
Interactions
molecular events
General
mitogen-activated protein kinase kinase kinase (MAP3K) or MEK kinase (MEKK)
Properties
SIZE: entity length = 619 aa
MW = 70 kD
COMPARTMENT: cytoplasm
cell nucleus
STATE: active state
MOTIF: OPR {43-122}
Ser phosphorylation site {S164}
Thr phosphorylation site {T304}
Ser phosphorylation site {S331}
kinase domain
SITE: 357-617
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 362-371
ATP-binding site
NAME: ATP-binding site
SITE: 385-385
aspartate residue {D483}
Thr phosphorylation site {T524}
References
UniProt :accession Q9Y2U5
Databases & Figures
UniProt Q9Y2U5
PFAM correlations
Entrez Gene 10746
ENZYME 2.7.11.25
MAP kinase pathways