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mitogen-activated protein kinase kinase kinase 14 (MAP3K14, NF kappa-B inducing kinase, NIK, HsNIK, MAP3K14)
Function:
- activated by lymphotoxin beta
- interacts with traf2, traf5, traf6, IKK-alpha (putative)
- role in activation of NF kappa-B
- induces processing of NF kappa-B 2/p100.
- activates MEK1 (putative)
- exclusively involved in the activation of NF-kappa-B & its transcriptional activity
- could act in a receptor-selective manner (putative)
- interacts with PELI3
- autophosphorylated
ATP + a protein ADP + a phosphoprotein
Structure:
- belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase kinase subfamily
- contains 1 protein kinase domain
Compartment: cytoplasm
Expression:
- weakly expressed in testis, small intestine, spleen, thymus, peripheral blood leukocytes, prostate, ovary & colon
Interactions
molecular events
General
mitogen-activated protein kinase kinase kinase (MAP3K) or MEK kinase (MEKK)
Properties
SIZE: entity length = 947 aa
MW = 104 kD
COMPARTMENT: cytoplasm
STATE: active state
MOTIF: kinase domain
SITE: 400-655
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 406-414
ATP-binding site
NAME: ATP-binding site
SITE: 429-429
aspartate residue {D515}
References
- Stancovski & Baltimore. Cell 91:299-302, 1997
- UniProt :accession Q99558
Databases & Figures
OMIM 604655
UniProt Q99558
Pfam PF00069
Entrez Gene 9020
Kegg hsa/hsa04210
ENZYME
Figures/diagrams/slides/tables related to MAP3K14/NF kappa-B inducing kinase