mitogen activated protein kinase kinase 7 (dual specificity mitogen-activated protein kinase kinase 7, JNK-activating kinase 2, c-jun N-terminal kinase kinase-2, JNKK2, MAPK/ERK kinase 7, MAP2K7, MEK7, MKK7, PRKMK7)

Function: - stress activated, dual specificity kinase - activates JUN kinases MAPK8/JNK1, MAPK9/JNK2 & MAPK10/JNK3 - activated by phosphorylation by specific MEK kinases such a MAP3K1/MEKK1, MAP3K3/MEKK3, MAP3K11/MLK3 & MAP3K12/DLK - activated by phosphorylation on Ser/Thr ATP + a protein ADP + a phosphoprotein Cofactor: Mg⁺² Structure: - belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family. MAP kinase kinase subfamily - contains 1 protein kinase domain Compartment: nucleus. cytoplasm (putative) Alternative splicing: named isoforms=4 Expression: - ubiquitous - highest level of expression in skeletal muscle - isoform 3 is found at low levels in placenta, fetal liver, & skeletal muscle

Properties

SIZE: entity length = 419 aa MW = 47 kD COMPARTMENT: cytoplasm cell nucleus STATE: active state MOTIF: coiled coil {1-30} proteolytic site {44-45} proteolytic site {76-77} kinase domain SITE: 120-380 MOTIF: ATP-binding site NAME: ATP-binding site SITE: 126-134 ATP-binding site NAME: ATP-binding site SITE: 149-149 aspartate residue {D243}

References

UniProt :accession O14733

Databases & Figures

OMIM 603014 UniProt O14733 Pfam PF00069 Entrez Gene 5609 ENZYME 2.7.12.2 MAP kinase pathways