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mitogen activated protein kinase kinase 4 (JNK-activating kinase 1, c-jun N-terminal kinase kinase-1, JNKK1, SAPK/ERK kinase 1, SERK1, MEK4, MAP2K4, MKK4, PRKMK4)
Function:
- dual specificity kinase that activates the JUN kinases MAPK8 (JNK1) & MAPK9 (JNK2) as well as MAPK14 (p38) but not MAPK1 (ERK2) or MAPK3 (ERK1)
- propagates intracellular kinase signalling downstream of ras
- interacts with SPAG9 (putative)
- activated by phosphorylation on Ser/Thr by MAP kinase kinase kinases (putative)
ATP + a protein ADP + a phosphoprotein
Structure:
- belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase subfamily
- contains 1 protein kinase domain
Expression:
- abundant expression in skeletal muscle
- widely expressed in other tissues
Interactions
molecular events
General
mitogen activated protein kinase kinase (MAP2K), MAPK/ERK kinase (MEK)
Properties
SIZE: entity length = 399 aa
MW = 44 kD
STATE: active state
MOTIF: serine-rich region {5-19}
MOTIF: serine residue (SEVERAL)
proteolytic site {45-46}
proteolytic site {58-59}
kinase domain
SITE: 102-367
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 108-116
ATP-binding site
NAME: ATP-binding site
SITE: 131-131
aspartate residue {D229}
References
- Lin A, Minden A, Martinetto H, Claret FX, Lange-Carter C,
Mercurio F, Johnson GL, Karin M.
Identification of a dual specificity kinase that activates the
Jun kinases and p38-Mpk2.
Science. 1995 Apr 14;268(5208):286-90.
PMID: 7716521
- UniProt :accession P45985
Databases & Figures
OMIM 601335
UniProt P45985
Pfam PF00069
Entrez Gene 6416
ENZYME 2.7.12.2
MAP kinase pathways