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mitogen activated protein kinase kinase 1 (MAP2K1, MAPK/ERK kinase 1, MEK1, dual specificity mitogen-activated protein kinase kinase 1, PRKMK1, ERK activator kinase 1)
Function:
- catalyzes concomitant phosphorylation of Thr & Tyr in a Thr-glu-Tyr sequence located in MAP kinases
- activates ERK1 & ERK2 MAP kinases
- interacts with MORG1 (putative)
- interacts with Yersinia yopJ
- activated by phosphorylation
- phosphorylation on Ser/Thr by MAP kinase kinase kinases (RAF or MEKK1) regulates positively the kinase activity
- acetylation by Yersinia yopJ prevents phosphorylation & activation, thus blocking MAPK signaling pathway
ATP + a protein ADP + a phosphoprotein
Structure:
- belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase subfamily
- contains 1 protein kinase domain
Pathology:
- defects in MAP2K1 are a cause of cardiofaciocutaneous syndrome
Interactions
molecular events
General
mitogen activated protein kinase kinase (MAP2K), MAPK/ERK kinase (MEK)
Properties
SIZE: entity length = 393 aa
MW = 43 kD
STATE: active state
MOTIF: proteolytic site {8-9}
kinase domain
SITE: 68-361
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 74-82
ATP-binding site
NAME: ATP-binding site
SITE: 97-97
aspartate residue {D190}
Ser phosphorylation site {S218}
Ser phosphorylation site {S222}
proline-rich region
SITE: 262-307
MOTIF: proline residue (SEVERAL)
References
- UniProt :accession Q02750
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=MAP2K1
Databases & Figures
OMIM correlations
MORBIDMAP 176872
UniProt Q02750
Pfam PF00069
Entrez Gene 5604
ENZYME 2.7.12.2
MAP kinase pathways