microtubule-associated protein 2; MAP-2 (MAP2)

Function: - exact function of MAP2 is unknown - may stabilize microtubules against depolymerization - may have a stiffening effect on microtubules - MAP2A is phosphorylated - phosphorylated upon DNA damage, probably by ATM or ATR Structure: contains 3 Tau/MAP repeats Compartment: cytoplasm, cytoskeleton (probable) Alternative splicing: named isoforms=3; MAP2A, MAP2B, MAP2C Additional isoforms seem to exist Expression: neurons Note: - some isoforms may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay

General

microtubule-associated protein (MAP) phosphoprotein

Properties

SIZE: entity length = 1827 aa MW = 200 kD COMPARTMENT: cytoplasm MOTIF: Ser phosphorylation site {S63} Ser phosphorylation site {S610} Ser phosphorylation site {S629} Ser phosphorylation site {S654} Ser phosphorylation site {S729} Ser phosphorylation site {S736} Tyr phosphorylation site {Y745} Ser phosphorylation site {S821} Ser phosphorylation site {S833} Ser phosphorylation site {S1155} Ser phosphorylation site {S1347} Ser phosphorylation site {S1353} Ser phosphorylation site {S1421} Thr phosphorylation site {T1440} binding site SITE: 1447-1467 FOR-BINDING-OF: calmodulin Ser phosphorylation site {S1480} Ser phosphorylation site {S1534} Ser phosphorylation site {S1591} Thr phosphorylation site {T1594} Thr phosphorylation site {T1595} Thr phosphorylation site {T1602} Thr phosphorylation site {T1605} Ser phosphorylation site {S1608} Ser phosphorylation site {S1611} Thr phosphorylation site {T1613} Thr phosphorylation site {T1616} Thr phosphorylation site {T1649} Tau/MAP {1661-1691} Tau/MAP {1692-1722} Tau/MAP {1723-1754} Ser phosphorylation site {S1782} Ser phosphorylation site {S1790} Ser phosphorylation site {S1798} Ser phosphorylation site {S1799} Ser phosphorylation site {S1800} Ser phosphorylation site {S1802}

Database Correlations

OMIM 157130 UniProt P11137 PFAM correlations Entrez Gene 4133