methionine aminopeptidase 1D, mitochondrial (MAP1D, METAP1D)

Function: - removes the amino-terminal methionine from nascent proteins (putative) - release of N-terminal amino acids, preferentially methionine, from peptides & arylamides Structure: belongs to the peptidase M24A family Compartment: mitochondria Pathology: - may play a role in colon tumorigenesis - overexpressed in colon cancer cell lines & colon tumors compared to normal tissues (at protein level) Note: - uncertain whether Met-1 or a Met upstream of this sequence is the initiator

General

methionyl aminopeptidase mitochondrial protein

Properties

SIZE: entity length = 335 aa MW = 37 kD COMPARTMENT: mitochondria MOTIF: histidine residue {H161}

Database Correlations

UniProt Q6UB28 Pfam PF00557 ENZYME 3.4.11.18

References

UniProt :accession Q6UB28