microtubule-associated protein 1B; MAP-1B; microtubule-associated protein 5; contains: MAP1 light chain LC1 (MAP1B)

Function: - function essentially - phosphorylated MAP1B may play a role in cytoskeletal changes that accompany neurite extension - may bind to at least two tubulin subunits in the polymer, & this bridging of subunits might be involved in nucleating microtubule polymerization & in stabilizing microtubules - MAP1 light chain LC1 is generated from MAP1B by proteolytic processing - phosphorylated upon DNA damage, probably by ATM or ATR - phosphorylated form involved in neurite outgrowth - 3 different light chains, LC1, LC2 & LC3, can associate with MAP1A & MAP1B proteins - LC1 interacts with the amino-terminal region of MAP1B - interacts with ANP32A & TIAM2 - interacts (via C-terminus) with GAN (via kelch domains) Structure: - highly basic region with many copies of the sequence KKEE & KKEI/V, repeated but not at fixed intervals, responsible for the binding of MAP1B to microtubules - belongs to the MAP1 family Expression: fetal protein Pathology: - phosphorylated form found in neurofibrillary tangles

General

microtubule-associated protein (MAP) phosphoprotein

Properties

SIZE: entity length = 2468 aa MW = 271 kD COMPARTMENT: cytoplasm MOTIF: Ser phosphorylation site {S336} Thr phosphorylation site {T527} Ser phosphorylation site {S541} Ser phosphorylation site {S544} Ser phosphorylation site {S561} Thr phosphorylation site {T569} lysine-rich region {589-790} MOTIF: lysine residue (SEVERAL) Ser phosphorylation site {S614} Ser phosphorylation site (7) {828-1016} Tyr phosphorylation site {Y1062} Thr phosphorylation site {T1067} Ser phosphorylation site (8) {1208-1280} Thr phosphorylation site {T1282} Ser phosphorylation site (3) {1312-1324} Tyr phosphorylation site {Y1336} Tyr phosphorylation site {Y1337} Ser phosphorylation site (15) {1339-1625} Thr phosphorylation site {T1633} Tyr phosphorylation site {Y1762} Ser phosphorylation site (3) {1772-1785} Thr phosphorylation site {T1788} Ser phosphorylation site {S1793} Tyr phosphorylation site {Y1796} Ser phosphorylation site (3) {1817-1819} Tyr phosphorylation site {Y1830} Tyr phosphorylation site {Y1870} Tyr phosphorylation site {Y1872} MAP1B {1878-1894} MOTIF: Ser phosphorylation site {S1881} MAP1B {1895-1911} MOTIF: Tyr phosphorylation site {Y1904} Tyr phosphorylation site {Y1905} MAP1B {1912-1928} MOTIF: Ser phosphorylation site {S1915} MAP1B {1929-1945} MOTIF: Thr phosphorylation site {T1932} Tyr phosphorylation site {Y1938} Tyr phosphorylation site {Y1940} MAP1B {1946-1962} MOTIF: Thr phosphorylation site {T1949} Tyr phosphorylation site {Y1957} MAP1B {1963-1979} MOTIF: Tyr phosphorylation site {Y1974} MAP1B {1997-2013} MAP1B {2014-2030} MOTIF: Tyr phosphorylation site {Y2025} MAP1B {2031-2047} MOTIF: Thr phosphorylation site {T2034} MAP1B {2048-2064} Ser phosphorylation site {S2072} Ser phosphorylation site {S2098} Ser phosphorylation site {S2209} Ser phosphorylation site {S2211} Ser phosphorylation site {S2289} Thr phosphorylation site {T2334}

Database Correlations

OMIM 157129 UniProt P46821 Pfam PF00414 Entrez Gene 4131