microtubule-associated protein 1A; MAP-1A; proliferation-related protein p80; contains: MAP1 light chain LC2 (MAP1A MAP1L)

Function: - structural protein involved in the filamentous cross- bridging between microtubules & other skeletal elements - phosphorylated upon DNA damage, probably by ATM or ATR - Ser may be phosphorylated by cAMP kinase - LC2 is generated from MAP1A by proteolytic processing - 3 different light chains, LC1, LC2 & LC3, can associate with MAP1A & MAP1B proteins - interacts with TIAM2 - interacts with guanylate kinase-like domain of DLG1, DLG2, DLG4 Structure: - the basic region (lysine-rich region) containing the repeats may be responsible for binding of MAP1A to microtubules - belongs to the MAP1 family Expression: brain

Properties

SIZE: entity length = 2805 aa MW = 306 kD COMPARTMENT: cytoplasm MOTIF: Ser phosphorylation site {S114} Tyr phosphorylation site {Y177} lysine-rich region {309-496} MOTIF: lysine residue (SEVERAL) 9 X 3 AA repeats of K-K-[DE] {415-541} MOTIF: consensus repeat {415-417} consensus repeat {420-422} consensus repeat {427-429} consensus repeat {431-433} consensus repeat {436-438} consensus repeat {440-442} consensus repeat {444-446} consensus repeat {449-451} Ser phosphorylation site {S526} Ser phosphorylation site {S527} consensus repeat {539-541} Ser phosphorylation site {S612} Thr phosphorylation site {T616} Ser phosphorylation site {S644} Ser phosphorylation site {S667} Tyr phosphorylation site {Y773} Ser phosphorylation site {S1326} Ser phosphorylation site {S1329} Ser phosphorylation site {S2019} Ser phosphorylation site {S2022} Ser phosphorylation site {S2252} Ser phosphorylation site {S2256} Ser phosphorylation site {S2260} Ser phosphorylation site {S2261}

Database Correlations

OMIM 600178 UniProt P78559 Entrez Gene 4130