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monoamine oxidase [MAO] inhibitor
Indications:
-> treatment of major depression*
Contraindications: Caution:
-> the sometimes severe & unpredictable interactions of MAO inhibitors with other drugs has favored use of other antidepressants
Adverse effects:
Toxicity:
- Manifestations:
- CNS stimulation, fever, tachycardia, tachypnea, hypertension, nausea, vomiting, dilated pupils, nystagmus, papilledema.
- Treatment:
- GI decontamination, activated charcoal, cathartics.
- Dantrolene (2.5 mg/kg PO or IV every 6 for hyperthermia.
- Nitroprusside for hypertension
- Propranolol for tachycardia
- Fluids for hypotension
- Benzodiazepines for seizures
Interactions
drug interactions
drug adverse effects (more general classes)
Specific
isocarboxazid (Marplan)
L-deprenyl (Selegiline, Eldepryl, Emsam, Zelapar)
lazabemide (Tempium, Ro-19-6327)
moclobemide (Aurorix, Manerix)
phenelzine (Nardil, Sinerval)
rasagiline (Azilect)
safinamide (Xadago)
tranylcypromine (Parnate)
General
antidepressant
enzyme inhibitor
References
- Goodman and Gilman's The Pharmacological Basis of
Therapeutics, 8th ed. Gilman et al, eds.
Permagon Press/McGraw Hill, 1990, pg 414
- Harrison's Principles of Internal Medicine, 13th ed.
Companion Handbook. Isselbacher et al (eds),
McGraw-Hill Inc. NY, 1995, pg 134.