Search
manganese in urine
Reference interval:
1) 0.5-9.8 ug/L (9.1-178 nmol/L)
2) toxic range > 10 ug/L (182 nmol/L)
Clinical significance:
- chronic inhalation of manganese damages the basal ganglia of the brain, resulting in parkinsonism
Increases:
1) chemical interferences
-> heparin therapy may contaminate specimen with Mn+2
2) clinical disorders
a) acute hepatitis
b) industrial exposure
1] foundry workers
2] welders
3] manufacture of drugs, glass, varnish, feed additives, ceramics
c) myocardial infarction
d) rheumatoid arthritis (erythrocytes)
Decreases:
-> clinical disorders
a) seizure disorder
b) phenylketonuria
Method:
- atomic absorption spectrometry (AAS)
Specimen:
- serum/urine/blood: collect in metal-free container
Notes:
- manganese is excreted primarily in the feces
Related
manganese [Mn]
Specific
manganese in 24 hour urine
General
manganese in body fluid
urine toxicology
References
- Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed.,
W.B. Saunders, 1995
- Medical Knowledge Self Assessment Program (MKSAP) 11, American
College of Physicians, Philadelphia 1998
Component-of
manganese/creatinine in urine