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manganese in specimen
Clinical significance:
- chronic inhalation of manganese damages the basal ganglia of the brain, resulting in parkinsonism
Increases:
1) chemical interferences
-> heparin therapy may contaminate specimen with Mn+2
2) clinical disorders
a) acute hepatitis
b) industrial exposure
1] foundry workers
2] welders
3] manufacture of drugs, glass, varnish, feed additives, ceramics
c) myocardial infarction
d) rheumatoid arthritis (erythrocytes)
Decreases:
-> clinical disorders
a) seizure disorder
b) phenylketonuria
Method:
- atomic absorption spectrometry (AAS)
Notes:
- most manganese in blood is bound to hemoglobin in erythrocytes
- manganese is excreted primarily in the feces
Related
manganese [Mn]
Specific
manganese in blood
manganese in body fluid
manganese in erythrocytes
manganese in hair
manganese in serum
manganese in tissue
manganese in urine
manganese in water
General
special chemistry test
References
- Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed.,
W.B. Saunders, 1995
- Medical Knowledge Self Assessment Program (MKSAP) 11, American
College of Physicians, Philadelphia 1998