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manganese in serum
Reference interval:
1) 0.59 +/- 0.16 ug/L (10.7 +/- 3.0 nmol/L) [1]
2) 0.14 ug/mL [2]
Clinical significance:
- chronic inhalation of manganese damages the basal ganglia of the brain, resulting in parkinsonism
Increases:
1) chemical interferences
-> heparin therapy may contaminate specimen with Mn+2
2) clinical disorders
a) acute hepatitis
b) industrial exposure
1] foundry workers
2] welders
3] manufacture of drugs, glass, varnish, feed additives, ceramics
c) myocardial infarction
d) rheumatoid arthritis (erythrocytes)
Decreases:
-> clinical disorders
a) seizure disorder
b) phenylketonuria
Method:
- atomic absorption spectrometry (AAS)
Specimen:
- serum/urine/blood: collect in metal-free container
Notes:
- most manganese in blood is bound to hemoglobin in erythrocytes
- manganese is excreted primarily in the feces
Related
manganese [Mn]
General
manganese in body fluid
References
- Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed.,
W.B. Saunders, 1995
- Medical Knowledge Self Assessment Program (MKSAP) 11, American
College of Physicians, Philadelphia 1998