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manganese in hair
Reference interval:
- 0.2-4.4 ug/g (3.6-80.1 nmol/g) dry weight
Clinical significance:
- chronic inhalation of manganese damages the basal ganglia of the brain, resulting in parkinsonism
Increases:
1) chemical interferences
-> heparin therapy may contaminate specimen with Mn+2
2) clinical disorders
a) acute hepatitis
b) industrial exposure
1] foundry workers
2] welders
3] manufacture of drugs, glass, varnish, feed additives, ceramics
c) myocardial infarction
d) rheumatoid arthritis (erythrocytes)
Decreases:
-> clinical disorders
a) seizure disorder
b) phenylketonuria
Method:
- atomic absorption spectrometry (AAS)
Specimen:
1) cut specimen close to scalp in 2-5 cm lengths
2) wash in acetone
3) digest in 70% ultrapure nitric acid
Related
manganese [Mn]
General
manganese in specimen
References
- Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed.,
W.B. Saunders, 1995
- Medical Knowledge Self Assessment Program (MKSAP) 11, American
College of Physicians, Philadelphia 1998