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mannosyl-oligosaccharide 1,2-alpha-mannosidase IA; alpha-1,2-mannosidase IA; mannosidase alpha class 1A member 1; man(9)-alpha-mannosidase; man9-mannosidase (MAN1A1)
Function:
- role in maturation of Asn-linked oligosaccharides
- progressively trims alpha-1,2-linked mannose residues from man(9)GlcNAc(2) to produce man(5)GlcNAc(2)
- inhibited by both 1-deoxymannojirimycin & kifunensine
- protein modification; protein glycosylation
- hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide man(9)(GlcNAc)(2)
Cofactor: Ca+2
Structure: belongs to the glycosyl hydrolase 47 family
Compartment: Golgi membrane
Laboratory:
- higher urinary levels of MAN1A1 portend a lower risk of death or hopsitalization for heart failure in patients with HFpEF [2]
General
alpha-mannosidase (MANA)
Ca+2 binding protein
glycoprotein
membrane protein
Properties
SIZE: entity length = 653 aa
MW = 73 kD
COMPARTMENT: golgi
MOTIF: transmembrane domain {42-62}
cysteine residue {C476}
MODIFICATION: cysteine residue {C508}
cysteine residue {C508}
MODIFICATION: cysteine residue {C476}
N-glycosylation site {N513}
Database Correlations
OMIM correlations
UniProt P33908
Pfam PF01532
Entrez Gene 4121
Kegg hsa:4121
ENZYME 3.2.1.113
References
- UniProt :accession P33908
- Carland C, Zhao L, Salman O et al
Urinary Proteomics and Outcomes in Heart Failure With Preserved Ejection Fraction.
J Am Heart Assoc. 2024 Apr 19:e033410.
PMID: 38639358 Free article.
https://www.ahajournals.org/doi/10.1161/JAHA.123.033410