MAM domain-containing glycosylphosphatidylinositol anchor protein 1; GPI & MAM protein; GPIM; glycosylphosphatidylinositol-MAM; MAM domain-containing protein 3 (MDGA1, MAMDC3)

Function: - required for radial migration of cortical neurons in the superficial layer of the neocortex (putative) - interacts heterophilically through its MAM domain with proteins in axon-rich regions & through its Ig-like domains with proteins in differentiating muscle (putative) Structure: - contains 1 fibronectin F3 module - contains 6 Ig-like (immunoglobulin-like) domains - contains 1 MAM domain Compartment: - cell membrane; lipid-anchor, GPI-anchor - associated with lipid rafts Alternative splicing: named isoforms=2 Expression: - expressed in brain, heart, skeletal muscle & kidney - overexpressed in tumor tissues

Properties

SIZE: entity length = 955 aa MW = 106 kD COMPARTMENT: plasma membrane CELL-REGION: apical region CELL: epithelial cell MOTIF: signal sequence {1-18} immunoglobulin superfamily domain {24-123} MOTIF: N-glycosylation site {N42} cysteine residue {C60} MODIFICATION: cysteine residue {C108} N-glycosylation site {N90} cysteine residue {C108} MODIFICATION: cysteine residue {C60} immunoglobulin superfamily domain {132-230} MOTIF: cysteine residue {C157} MODIFICATION: cysteine residue {C214} cysteine residue {C214} MODIFICATION: cysteine residue {C157} N-glycosylation site {N235} immunoglobulin superfamily domain {240-323} MOTIF: N-glycosylation site {N247} N-glycosylation site {N257} cysteine residue {C262} MODIFICATION: cysteine residue {C308} N-glycosylation site {N307} cysteine residue {C308} MODIFICATION: cysteine residue {C262} N-glycosylation site {N331} immunoglobulin superfamily domain {338-432} MOTIF: cysteine residue {C357} MODIFICATION: cysteine residue {C415} cysteine residue {C415} MODIFICATION: cysteine residue {C357} N-glycosylation site {N432} immunoglobulin superfamily domain {440-532} MOTIF: cysteine residue {C463} MODIFICATION: cysteine residue {C514} cysteine residue {C514} MODIFICATION: cysteine residue {C463} immunoglobulin superfamily domain {539-631} MOTIF: cysteine residue {C560} MODIFICATION: cysteine residue {C615} cysteine residue {C615} MODIFICATION: cysteine residue {C560} fibronectin type III domain or F3 module {640-739} MOTIF: N-glycosylation site {N655} N-glycosylation site {N747} MAM domain {751-918} MOTIF: cysteine residue {*1} (2) MODIFICATION: cysteine residue {*2} cysteine residue {*2} (2) MODIFICATION: cysteine residue {*1} N-glycosylation site {N826} glycosyl phosphatidylinositol [GPI] membrane anchor {N932}

Database Correlations

OMIM 609626 UniProt Q8NFP4 PFAM correlations Entrez Gene 266727 Kegg hsa:266727

References

UniProt :accession Q8NFP4