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MAM domain-containing glycosylphosphatidylinositol anchor protein 2; MAM domain-containing protein 1 (MDGA2, MAMDC1, UNQ8188/PRO23197)
Function:
- may involved in cell-cell interactions (putative)
Structure:
- contains 6 Ig-like (immunoglobulin-like) domains
- contains 1 MAM domain
Compartment: cell membrane; lipid-anchor, GPI-anchor
Alternative splicing: named isoforms=2
General
glypiated protein
Properties
SIZE: entity length = 956 aa
MW = 107 kD
COMPARTMENT: plasma membrane
CELL-REGION: apical region
CELL: epithelial cell
MOTIF: signal sequence {1-25}
immunoglobulin superfamily domain {27-127}
MOTIF: cysteine residue {C62}
MODIFICATION: cysteine residue {C110}
N-glycosylation site {N92}
cysteine residue {C110}
MODIFICATION: cysteine residue {C62}
immunoglobulin superfamily domain {134-232}
MOTIF: cysteine residue {C159}
MODIFICATION: cysteine residue {C216}
N-glycosylation site {N213}
cysteine residue {C216}
MODIFICATION: cysteine residue {C159}
N-glycosylation site {N237}
immunoglobulin superfamily domain {242-328}
MOTIF: cysteine residue {C264}
MODIFICATION: cysteine residue {C310}
cysteine residue {C310}
MODIFICATION: cysteine residue {C264}
immunoglobulin superfamily domain {340-436}
MOTIF: cysteine residue {C359}
MODIFICATION: cysteine residue {C417}
cysteine residue {C417}
MODIFICATION: cysteine residue {C359}
N-glycosylation site {N434}
immunoglobulin superfamily domain {442-533}
MOTIF: N-glycosylation site {N443}
cysteine residue {C465}
MODIFICATION: cysteine residue {C515}
N-glycosylation site {N504}
cysteine residue {C515}
MODIFICATION: cysteine residue {C465}
immunoglobulin superfamily domain {540-627}
MOTIF: cysteine residue {C561}
MODIFICATION: cysteine residue {C611}
N-glycosylation site {N610}
cysteine residue {C611}
MODIFICATION: cysteine residue {C561}
N-glycosylation site {N703}
MAM domain {746-921}
MOTIF: cysteine residue {*1} (2)
MODIFICATION: cysteine residue {*2}
cysteine residue {*2} (2)
MODIFICATION: cysteine residue {*1}
glycosyl phosphatidylinositol [GPI] membrane anchor {N931}
Database Correlations
OMIM 611128
UniProt Q7Z553
PFAM correlations
Entrez Gene 161357
Kegg hsa:161357
References
UniProt :accession Q7Z553