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mucosa-associated lymphoid tissue lymphoma translocation protein 1; MALT lymphoma-associated translocation; paracaspase (MALT1, MLT)
Function:
- enhances BCL10-induced activation of NF-kappa-B
- role in nuclear export of BCL10
- binds to TRAF6, inducing TRAF6 oligomerization & activation of its ligase activity
- has ubiquitin ligase activity
- MALT1-dependent BCL10 cleavage plays a role in T-cell antigen receptor-induced integrin adhesion
- binds through its Ig-like domains to BCL10
- forms oligomers which bind to TRAF6
Structure:
- belongs to the peptidase C14B family
- contains 1 death domain
- contains 2 Ig-like C2-type domains
Compartment:
- cytoplasm, perinuclear region, nucleus
- shuttles between the nucleus & cytoplasm
- found in perinuclear structures together with BCL10
Alternative splicing: named isoforms=2
Expression:
- highly expressed in peripheral blood mononuclear cells
- expressed at lower levels in bone marrow, thymus & lymph node
- expressed at very low levels in colon & lung
Pathology:
- chromosomal translocation t(11;18)(q21;q21) involving MALT1 with BIRC3 is found in ~50% of cytogenetically abnormal low-grade MALT lymphomas
Related
extranodal marginal zone B-cell lymphoma; low grade B-cell lymphoma of MALT [mucosa associated lymphoid tissue] type, MALToma
mucosa-associated lymphoid tissue lymphoma translocation gene 1 (MALT1)
General
cysteine proteinase; thiol proteinase
phosphoprotein
Properties
SIZE: entity length = 824 aa
MW = 92 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: death domain
NAME: death domain
SITE: 39-126
immunoglobulin superfamily domain {125-201}
MOTIF: breakpoint {126-127}
Ser phosphorylation site {S135}
cysteine residue {C147}
MODIFICATION: cysteine residue {C190}
cysteine residue {C190}
MODIFICATION: cysteine residue {C147}
immunoglobulin superfamily domain {212-305}
MOTIF: breakpoint {216-217}
cysteine residue {C248}
MODIFICATION: cysteine residue {C290}
cysteine residue {C290}
MODIFICATION: cysteine residue {C248}
breakpoint {320-321}
breakpoint {323-324}
breakpoint {329-330}
Caspase-like {348-562}
MOTIF: nuclear export signal {369-376}
histidine residue {H415}
cysteine residue {C464}
Database Correlations
OMIM 604860
UniProt Q9UDY8
PFAM correlations
Entrez Gene 10892
Kegg hsa:10892
ENZYME 3.4.22.-
References
- UniProt :accession Q9UDY8
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/MALT1ID240.html