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malignant glioma
high grade gliomas
Management:
1) external beam radiation therapy
2) may be small benefit of adjuvant chemotherapy [2]
Notes:
- gliomas are relatively resistant to chemotherapy & radiation
Interactions
disease interactions
Specific
anaplastic astrocytoma (grade 3)
anaplastic ependymoma
anaplastic oligodendroglioma
glioblastoma multiforme (GBM) or astrocytoma grade IV
General
glial neoplasm (glioma)
malignant brain tumor
sarcoma
References
- Radiotherapy for newly diagnosed malignant glioma in adults
Program in Evidence-Based Care (PEBC)
http://www.cancercare.on.ca/pdf/pebc9-3f.pdf
- Glioma Meta-Analysis Trialists (GMT) Group.
Chemotherapy for high-grade glioma.
Cochrane Database Syst Rev. 2002;(4):CD003913.
PMID: 12519620
- Laws ER, Parney IF, Huang W, Anderson F et al
Survival following surgery and prognostic factors for
recently diagnosed malignant glioma: data from the Glioma
Outcomes Project.
J Neurosurg. 2003 Sep;99(3):467-73
PMID: 1295943
- Stupp R, Hegi ME, Gilbert MR, Chakravarti A.
Chemoradiotherapy in malignant glioma: standard of care and
future directions.
J Clin Oncol. 2007 Sep 10;25(26):4127-36.
PMID: 17827463