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myelin-associated glycoprotein; siglec-4a (MAG GMA)
Function:
- adhesion molecule in postnatal neural development
- mediates sialic-acid dependent cell-cell interactions between neuronal & myelinating cells (oligodendrocytes)
- preferentially binds to alpha-2,3-linked sialic acid (putative)
- binds to RTN4R (putative)
Structure:
- belongs to the immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family
- contains 4 Ig-like C2-type domains (immunoglobulin-like)
- contains 1 Ig-like V-type domain (immunoglobulin-like)
Compartment: membrane
Pathology:
- IgM monoclonal antibody binds to MAG in ~50% of patients with MGUS
Interactions
molecular events
Related
anti-myelin-associated glycoprotein (MAG)
myelin-associated glycoprotein (MAG) Ab in body fluid
myelin-associated glycoprotein (MAG) Ab in CSF
myelin-associated glycoprotein (MAG) Ab in serum
myelin-associated glycoprotein (MAG) IgA in serum
myelin-associated glycoprotein (MAG) IgG in serum
myelin-associated glycoprotein (MAG) IgM in serum
General
adhesion receptor
glycoprotein
immunoglobulin superfamily protein
myelin protein
phosphoprotein
Properties
SIZE: entity length = 626 aa
MW = 69 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-19}
immunoglobulin superfamily domain {22-120}
MOTIF: cysteine residue {C37}
MODIFICATION: cysteine residue {C165}
cysteine residue {C42}
MODIFICATION: cysteine residue {C100}
N-glycosylation site {N99}
cysteine residue {C100}
MODIFICATION: cysteine residue {C42}
N-glycosylation site {N106}
binding site
SITE: 118-118
FOR-BINDING-OF: Sialic acid
immunoglobulin superfamily domain {139-237}
MOTIF: cysteine residue {C159}
MODIFICATION: cysteine residue {C217}
cysteine residue {C165}
MODIFICATION: cysteine residue {C37}
cysteine residue {C217}
MODIFICATION: cysteine residue {C159}
N-glycosylation site {N223}
immunoglobulin superfamily domain {241-325}
MOTIF: N-glycosylation site {N246}
cysteine residue {C261}
MODIFICATION: cysteine residue {C305}
cysteine residue {C305}
MODIFICATION: cysteine residue {C261}
N-glycosylation site {N315}
immunoglobulin superfamily domain {327-412}
MOTIF: asparagine residue {332}
cysteine residue {C347}
MODIFICATION: cysteine residue {C392}
cysteine residue {C392}
MODIFICATION: cysteine residue {C347}
N-glycosylation site {N406}
immunoglobulin superfamily domain {413-508}
MOTIF: cysteine residue {C421}
MODIFICATION: cysteine residue {C430}
cysteine residue {C430}
MODIFICATION: cysteine residue {C421}
cysteine residue {C432}
MODIFICATION: cysteine residue {C488}
N-glycosylation site {N450}
N-glycosylation site {N454}
cysteine residue {C488}
MODIFICATION: cysteine residue {C432}
transmembrane domain {517-536}
MOTIF: cysteine residue {C531}
MODIFICATION: palmitate
COMPARTMENT: membrane
Database Correlations
OMIM 159460
UniProt P20916
PFAM correlations
Entrez Gene 4099
Kegg hsa:4099
References
- Schachner M, Martini R.
Glycans and the modulation of neural-recognition molecule function.
Trends Neurosci. 1995 Apr;18(4):183-91. Review.
PMID: 7539963
- Entrez Gene :accession 4099
- UniProt :accession P20916
- Functional glycomics gateway - glycan binding Note: siglec-4
http://www.functionalglycomics.org/glycomics/GBPServlet?&operationtype=view&cbpId=cbp_hum_Itlect_271
- ARUP laboratories
Anti-MAG and Anti-SGPG, IgM
SERODIAGNOSIS OF AUTOIMMUNE NEUROPATHIES
http://www.aruplab.com/Testing-Information/resources/TechnicalBulletins/Anti-MAG%20and%20Anti-SGPG,%20IgM.pdf
Component-of
molecular complex