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platelet basic protein; PBP; C-X-C motif chemokine 7; small-inducible cytokine B7; leukocyte-derived growth factor; LDGF; macrophage-derived growth factor; MDGF (PPBP, CTAP3, CXCL7, SCYB7)
Function:
- LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, & synthesis of hyaluronic acid & sulfated glycosaminoglycan
- it also stimulates the formation & secretion of plasminogen activator by human synovial cells
- NAP-2 is a ligand for CXCR1 & CXCR2, & NAP-2, NAP-2(73), NAP-2(74), NAP-2(1-66), & most potent NAP-2(1-63) are chemoattractants & activators for neutrophils
- TC-1 & TC-2 are antibacterial proteins, in vitro released from activated platelet alpha-granules
- proteolytic removal of residues 1-9 produces the active peptide connective tissue-activating peptide III (CTAP-III) (low- affinity platelet factor IV (LA-PF4))
- CTAP-III(1-81) is more potent than CTAP-III; both desensitize chemokine-induced neutrophil activation
- proteolytic removal of residues 1-13 produces the active peptide beta-thromboglobulin, which is released from platelets along with platelet factor 4 & platelet-derived growth factor NAP-2(1-66) is produced by proteolytical processing, probably after secretion by leukocytes other than neutrophils NAP-2(73) & NAP-2(74) seem not be produced by proteolytical processing of secreted precursors but are released in an active form from platelets
Structure:
- belongs to the intercrine alpha (chemokine CxC) family
Compartment: secreted
Specific
beta-thromboglobulin 1 (TGB1, THBGB1)
connective-tissue activating peptide III
neutrophil-activating peptide-2 (NAP-2)
General
CXC chemokine; alpha chemokine
thromboglobulin (TGB)
Properties
SIZE: entity length = 128 aa
MW = 14 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-34}
cysteine residue {C63}
MODIFICATION: cysteine residue {C89}
cysteine residue {C65}
MODIFICATION: cysteine residue {C105}
cysteine residue {C89}
MODIFICATION: cysteine residue {C63}
cysteine residue {C105}
MODIFICATION: cysteine residue {C65}
References
- UniProt :accession P02775
- Wikipedia: CXCL7 entry
http://en.wikipedia.org/wiki/CXCL7
Databases & Figures
OMIM 121010
UniProt P02775
Pfam PF00048
Entrez Gene 5473
Kegg hsa:5473
CXC ligand and receptor binding