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muscarinic M4 receptor; muscarinic acetylcholine receptor M4 (CHRM4)
Function:
- primary transducing effect is inhibition of adenylate cyclase (via Gi protein) Structure: belongs to the G-protein coupled receptor 1 family Compartment:
- cell membrane; cell junction, synapse
- postsynaptic cell membrane
General
muscarinic receptor
phosphoprotein
Properties
SIZE: entity length = 479 aa
MW = 53 kD
COMPARTMENT: synaptic membrane
CELL: neuron
MOTIF: exoplasmic domain {1-31}
MOTIF: N-glycosylation site {N8}
N-glycosylation site {N13}
transmembrane domain {32-54}
cytoplasmic domain {55-68}
transmembrane domain {69-89}
exoplasmic domain {90-106}
MOTIF: cysteine residue {C105}
MODIFICATION: cysteine residue {C185}
transmembrane domain {107-128}
cytoplasmic domain {129-148}
transmembrane domain {149-171}
exoplasmic domain {172-193}
MOTIF: cysteine residue {C185}
MODIFICATION: cysteine residue {C105}
transmembrane domain {194-216}
cytoplasmic domain {217-401}
MOTIF: src homology 3 [SH3] domain
SITE: LOOP-L3
transmembrane domain {402-422}
exoplasmic domain {423-436}
transmembrane domain {437-456}
cytoplasmic domain {457-479}
MOTIF: Thr phosphorylation site {T459}
Thr phosphorylation site {T463}
Thr phosphorylation site {T477}
MISC-INFO: Ki [PIRENZEPINE] LOW
INHIBITOR = PD102807
INHIBITOR = TROPICAMIDE
INHIBITOR = MT_3
Database Correlations
OMIM 118495
UniProt P08173
Pfam PF00001
Entrez Gene 1132
Kegg hsa:1132
References
- Conklin BR, Brann MR, Buckley NJ, Ma AL, Bonner TI, Axelrod J.
Stimulation of arachidonic acid release and inhibition of
mitogenesis by cloned genes for muscarinic receptor subtypes
stably expressed in A9 L cells.
Proc Natl Acad Sci U S A. 1988 Nov;85(22):8698-702.
PMID: 2847172
- UniProt :accession P08173