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lysozyme-C; 1,4-beta N-acetylmuramidase C (LYZ, LZM)
Function:
- lysozymes have primarily a bacteriolytic function
- lysozymes in tissues & body fluids are associated with the monocyte-macrophage system
- lysozymes hydrolyze of (1->4)-beta-linkages between N-acetylmuramic acid & N-acetyl-D-glucosamine residues in a peptidoglycan & between N-acetyl-D-glucosamine residues in chitodextrins
- lysozyme C is capable of both hydrolysis & transglycosylation
- slight esterase activity
- acts rapidly on both peptide-substituted & unsubstituted peptidoglycan, & slowly on chitin oligosaccharides
Structure:
- monomer
- belongs to the glycosyl hydrolase 22 family
Pathology:
- defects in LYZ are a cause of amyloidosis type 8
General
muramidase or lysozyme
Properties
SIZE: entity length = 148 aa
MW = 17 kD
COMPARTMENT: lysosome
serum
exocrine secretion
MOTIF: signal sequence {1-18}
cysteine residue {C24}
MODIFICATION: cysteine residue {C146}
cysteine residue {C48}
MODIFICATION: cysteine residue {C134}
glutamate residue {E53}
aspartate residue {D71}
active site
glycosylation site
cysteine residue {C83}
MODIFICATION: cysteine residue {C99}
cysteine residue {C95}
MODIFICATION: cysteine residue {C113}
cysteine residue {C99}
MODIFICATION: cysteine residue {C83}
cysteine residue {C113}
MODIFICATION: cysteine residue {C95}
cysteine residue {C134}
MODIFICATION: cysteine residue {C48}
cysteine residue {C146}
MODIFICATION: cysteine residue {C24}
Database Correlations
OMIM correlations
UniProt P61626
Pfam PF00062
Entrez Gene 4069
Kegg hsa:4069
ENZYME 3.2.1.17
References
- UniProt :accession P61626
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=LYZ
- Wikipedia; Note: lysozyme entry
http://en.wikipedia.org/wiki/lysozyme