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mitotane (Lysodren)

Tradename: Lysodren. Indications: - treatment of inoperable adrenal cortical carcinoma - Cushing's syndrome [3] Contraindications: Caution: - may impair ability to drive or operate hazardous equipment Dosage: Tabs: 500 mg Storage: Protect from light Adverse effects: 1) common (> 10%) - diarrhea, hyperpigmentation, anorexia, depression, dizziness 2) less common (1-10%) - double vision, blurred vision, hemorrhagic cystitis, orthostatic hypotension, myalgia, fever, flushing of skin 3) uncommon (< 1%) - shortness of breath, wheezing, lethargy, somnolence, irritability, confusion, tremors, weakness, fatigue, headache, rash, nausea/vomiting Drug interactions: 1) barbiturates 2) warfarin 3) phenytoin 4) CNS depressants Test interactions: increases serum K+ Mechanism of action: adrenocortical suppression

General

antineoplastic endocrine agent

Database Correlations

PUBCHEM cid=4211

References

  1. Kaiser Permanente Northern California Regional Drug Formulary, 1998
  2. Deprecated Reference
  3. Department of Veterans Affairs, VA National Formulary