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lypressin (lysine vasopressin, Diapid)
Tradename: Diapid.
Indications:
- used to control polyuria, polydipsia & dehydration in patients with central diabetes insipidus
Contraindications:
Pregnancy category: C
Safety in lactation: ?
Dosage:
- 1-2 sprays intranasally QID PRN.
Bottles: 8 mL.
Pharmacokinetics:
- elimination: liver, kidney
Adverse effects:
1) generally infrequent & mild
2) rhinorrhea
3) nasal congestion
4) nasal irritation
5) periorbital edema
6) headache
7) abdominal cramps
8) slight increase in blood pressure
Drug interactions:
- carbamazepine, chlorpropamide may potentiate effects of lypressin
Mechanism of action:
1) synthetic lysine vasopressin analog
2) antidiuretic properties with no vasopressor or oxytocic effects
General
vasopressin (antidiuretic hormone, ADH)
endocrine agent
References
- The Pharmacological Basis of Therapeutics, 9th ed.
Gilman et al, eds. Permagon Press/McGraw Hill, 1996
- Drug Information & Medication Formulary, Veterans Affairs,
Central California Health Care System, 1st ed., Ravnan et al
eds, 1998 - not on National VA formulary