Ly6/PLAUR domain-containing protein 3 (GPI-anchored metastasis-associated protein C4.4A homolog, matrigel-induced gene C4 protein, MIG-C4, LYPD3, C44A, UNQ491/PRO1007)

Function: 1) supports cell migration 2) role in urothelial cell-matrix interactions (putative) 3) binds laminin-1 & laminin-5 4) interacts with LGALS3, AGR2 & AGR3 Structure: - N-glycosylated & O-glycosylated - contains 2 UPAR/Ly6 domains Mass Spectroscopy: MW=21442.9 Compartment: cell membrane, GPI-anchor Expression: - expressed in placenta, skin & urothelium - found in suprabasal keratinocytes of chronic wounds - weak expression in esophagus & peripheral blood mononuclear cells - up-regulated in migrating keratinocytes during epithelization of incisional skin wounds. Pathology: - role in tumor progression (putative) - found in the majority of primary & metastatic transitional cell carcinomas & breast cancers, but not in adjacent normal tissues - high expression in the tumor component of some noninvasive superficial lesions & in invasive & metastatic urothelial cancers

General

glypiated protein Ly6/PLAUR domain-containing protein (LYPD)

Properties

SIZE: MW = 36 kD entity length = 346 aa COMPARTMENT: plasma membrane CELL-REGION: apical region CELL: epithelial cell MOTIF: signal sequence {1-30} UPAR/Ly6 1 {33-126} MOTIF: N-glycosylation site {N118} UPAR/Ly6 2 {140-222} MOTIF: N-glycosylation site {N163} N-glycosylation site {N176} N-glycosylation site {N183} glycosyl phosphatidylinositol [GPI] membrane anchor {N326}

Database Correlations

UniProt O95274 Pfam PF00021

References

UniProt :accession O95274