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lymphoplasmacytic lymphoma/immunocytoma
Immunophenotype:
- surface & cytoplasmic Ig, usually IgM +
- B-cell antigens (CD19, CD20, CD22, CD79a) +
- CD5 -
- CD10 -
- CD43 +/-
Genetics: Ig heavy & light chain genes rearranged.
Clinical manifestations:
- majority have Waldenstrom's macroglobulinemia
- hyperviscosity 10-30%
- neuropathies (paraprotein)
- cryoglobulinemia
- coagulopathy
Laboratory:
- IgM paraprotein reactivity to myelin sheath antigens such as MAG or gangliosides ~10%
Interactions
disease interactions
General
lymphoid leukemia
peripheral B-cell lymphoid neoplasm
small lymphocytic lymphoma