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lung cancer

Primary lung cancers are predominantly lung carcinomas. Etiology: - risk factors (see lung carcinoma) Epidemiology: - leading cause of cancer-related death world-wide [5] - incidence declining in men & young adults in association with declining rates of smoking 2005-2009 [7] Pathology: 1) lung small cell carcinoma (14%) a) occurs almost exclusively in smokers b) invariably metastatic on presentation 2) lung squamous cell carcinoma (20%) - tends to occur more centrally 3) lung adenocarcinoma (38%) a) most common type in non-smokers b) tends to occur more peripherally 4) lung bronchoalveolar carcinoma (lung adenocarcinoma, 3%) -> low-grade carcinoma frequently presenting as patchy infiltrate 5) lung large cell carcinoma (3%) 6) lung adenosquamous carcinoma (0.6-2.3%) 7) lung bronchial carcinoid (1-2%) 8) sarcomatoid carcinoma (0.3%) 9) mesothelioma 10) lung mucoepidermoid carcinoma (0.1%) 11) lung adenoid cystic carcinoma (< 0.1%) 12) metastases a) lymph node metastases (83% local, 29% distant) b) liver metastases (73%) c) ipsilateral or contralateral lung metastases(8%) d) bone metastases(56%) e) brain metastases (37%) f) adrenal metastases (35%) g) kidney metastases (16%) [5] Clinical manifestations: (see lung carcinoma) Laboratory: - tissue diagnosis (histopathology) needed for diagnosis [5] - lung biopsy - needle aspiration rather than biopsy of lymph node diagnostic [5] - see ARUP consult [5] Special laboratory: (see lung carcinoma) Radiology: (see lung carcinoma) Complications: (see lung carcinoma) Management: (see lung carcinoma)

Interactions

disease interactions

Related

lung cancer genotyping lung cancer pathogensis - genetic & pathways mediastinal neoplasm pleural neoplasm pulmonary metastases screening for lung cancer staging of lung cancer

Specific

carcinoma of the lung Pancoast tumor (superior pulmonary sulcus tumor) secondary lung cancer

General

lung neoplasm Malignant Neoplasm of Respiratory & Intrathoracic Organs

Database Correlations

OMIM 211980

References

  1. Saunders Manual of Medical Practice, Rakel (ed), WB Saunders, Philadelphia, 1996, pg 30
  2. Mayo Internal Medicine Board Review, 1998-99, Prakash UBS (ed) Lippincott-Raven, Philadelphia, 1998, pg 671-673, 766-69
  3. Harrison's Principles of Internal Medicine, 14th ed. Fauci et al (eds), McGraw-Hill Inc. NY, 1998, pg 521, 553
  4. Pathology of the Lungs. Corrin. Churchill-Livingstone 2000
  5. Medical Knowledge Self Assessment Program (MKSAP) 16, 17, 19. American College of Physicians, Philadelphia 2012, 2015, 2022
  6. ARUP Consult: Lung Cancer deprecated reference
  7. Centers for Disease Control and Prevention (CDC) Lung Cancer Incidence Trends Among Men and Women - United States, 2005-2009 MMWR. Jan 10, 2014 http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6301a1.htm
  8. Kvale PA1, Selecky PA, Prakash UB for the American College of Chest Physicians. Palliative care in lung cancer: ACCP evidence-based clinical practice guidelines (2nd edition). Chest. 2007 Sep;132(3 Suppl):368S-403S. PMID: 17873181
  9. Collins LG, Haines C, Perkel R, Enck RE. Lung cancer: diagnosis and management. Am Fam Physician. 2007 Jan 1;75(1):56-63. Review. PMID: 17225705 Free Article
  10. Alberts WM; American College of Chest Physicians. Diagnosis and management of lung cancer executive summary: ACCP evidence-based clinical practice guidelines (2nd Edition). Chest. 2007 Sep;132(3 Suppl):1S-19S. PMID: 17873156
  11. Henley SJ, Richards TB, Underwood JM et al Lung cancer incidence trends among men and women-- United States, 2005-2009. MMWR Morb Mortal Wkly Rep. 2014 Jan 10;63(1):1-5. PMID: 24402465 Free full text
  12. Alberts WM; American College of Chest Physicians. Diagnosis and management of lung cancer executive summary: ACCP evidence-based clinical practice guidelines (2nd Edition). Chest. 2007 Sep;132(3 Suppl):1S-19S. PMID: 17873156 - Comment in: There are major problems with the American College of Chest Physicians Second Lung Cancer Guidelines. [Chest. 2008] PMID: 17873156
  13. Dholaria B, Hammond W, Shreders A, Lou Y. Emerging therapeutic agents for lung cancer. J Hematol Oncol. 2016 Dec 9;9(1):138. Review. PMID: 27938382 Free PMC Article
  14. Bade BC, Silvestri GA Palliative Care in Lung Cancer: A Review. Semin Respir Crit Care Med. 2016 Oct;37(5):750-759. Review. PMID: 27732996
  15. Rivera MP, Mehta AC, Wahidi MM. Establishing the diagnosis of lung cancer: diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest. 2013;143:e142S-e165S. PMID: 23649436