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leucine-rich repeat flightless-interacting protein 2 (LRR FLII- interacting protein 2, LRRFIP2)
Function:
- may function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin
- interacts with DVL3 & FLII
Structure: belongs to the LRRFIP family
Alternative splicing: named isoforms=3
Expression:
- ubiquitous
- higher expression in heart & skeletal muscle
General
leucine-rich repeat-containing protein (LRRC)
phosphoprotein
Properties
SIZE: MW = 82 kD
entity length = 721 aa
MOTIF: binding site
SITE: 1-370
FOR-BINDING-OF: segment polarity protein dishevelled homolog DVL-3
MOTIF: coiled coil {22-49}
serine-rich region {118-342}
MOTIF: serine residue (SEVERAL)
Ser phosphorylation site {S328}
Thr phosphorylation site {T331}
Ser phosphorylation site {S333}
coiled coil {349-524}
coiled coil {566-714}
Database Correlations
UniProt Q9Y608
References
UniProt :accession Q9Y608