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leucine-rich repeat flightless-interacting protein 1 (LRR FLII-interacting protein 1, TAR RNA-interacting protein, GC-binding factor 2, LRRFIP1, GCF2, TRIP)
Function:
1) transcriptional repressor
2) preferentially binds to GC-rich consensus sequence (5'-AGCCCCCGGCG-3')
3) regulates expression of TNF, EGFR & PDGFA (putative)
4) controls smooth muscle cell proliferation following artery injury through PDGFA repression (putative)
5) binds double-stranded RNA (putative)
6) interacts with FLI
Compartment: nucleus, cytoplasm
Alternative splicing: named isoforms=3
Expression:
- ubiquitously expressed
- widely expressed in fetal tissues
General
phosphoprotein
RNA-binding protein
Properties
SIZE: MW = 89 kD
entity length = 808 aa
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: Ser phosphorylation site {S16}
coiled coil {128-250}
binding site
SITE: 485-584
FOR-BINDING-OF: deoxyribonucleic acid (DNA)
MOTIF: Ser phosphorylation site {S521}
lysine-rich region {567-593}
MOTIF: lysine residue (SEVERAL)
Ser phosphorylation site {S714}
Database Correlations
OMIM 603256
UniProt Q32MZ4
References
UniProt :accession Q32MZ4