leucine-rich repeat-containing protein 26 (cytokeratin-associated protein, LRRC26, CAPC)

Structure: - contains 6 LRR repeats (leucine-rich repeats) Compartment: - membrane (putative), cytoplasm, cytoskeleton - although predicted to be a single-pass type 1 membrane protein, localizes in cytoplasm when expressed at high levels Expression: - expressed highly in normal prostate & salivary gland - weak expression in colon, pancreas, & intestine - not expressed in other tissues Pathology: - expressed highly in many cancer cell lines & in breast cancer, pancreatic cancer & colon cancer

Properties

SIZE: entity length = 334 aa MW = 35 kD COMPARTMENT: cellular membrane MOTIF: signal sequence {1-26} leucine-rich repeat SITE: 70-93 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 95-117 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 118-141 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 143-165 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 166-189 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 191-217 MOTIF: leucine residue (SEVERAL) transmembrane domain {262-282}

Database Correlations

UniProt Q2I0M4 Pfam PF00560

References

UniProt :accession Q2I0M4