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leucine-rich repeat & death domain-containing protein (p53-induced protein with a death domain, LRDD, PIDD)
Function:
1) promotes apoptosis downstream of p53
2) component of the DNA damage/stress response pathway
3) associates with NEMO/IKBKG & RIP1
4) enhances sumoylation & ubiquitination of NEMO/IKBKG,
5) associates with CASP2/caspase-2 & CRADD/RAIDD
- induces activation of CASP2
6) interacts with FADD & MAP-kinase activating death domain/MADD
7) forms a complex with IKBKG & with RIP1
8) forms a complex named PIDDosome with CASP2 & CRADD
9) induced by gamma-irradiation
Expression: ubiquitous
General
other protein
Properties
SIZE: MW = 100 kD
entity length = 910 aa
MOTIF: leucine-rich repeat
SITE: 124-147
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 149-170
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 171-193
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 194-216
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 218-239
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 241-262
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 263-285
MOTIF: leucine residue (SEVERAL)
ZU5 1 {315-422}
ZU5 2 {453-565}
death domain
NAME: death domain
SITE: 788-873
Database Correlations
OMIM 605247
UniProt Q9HB75
References
UniProt :accession Q9HB75