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Lysophosphatidic acid receptor 3; LPA receptor 3; LPA-3; Lysophosphatidic acid receptor Edg-7 (LPAR3, EDG7, LPA3)
Function:
1) receptor for lysophosphatidic acid (LPA)
2) coupled to the Gi proteins, Go proteins & Gq proteins
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane; multi-pass membrane protein
Expression:
- expressed in prostate, testes, pancreas, & heart > lung & ovary
- no detectable expression in brain, placenta, liver, skeletal muscle, kidney, spleen, thymus, small intestine, colon, or peripheral blood leukocytes
Pathology:
- may play a role in development of ovarian cancer
General
glycoprotein
lysophosphatidic acid receptor (LPA-R)
Properties
SIZE: MW = 40 kD
entity length = 353 aa
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-31}
MOTIF: N-glycosylation site {N15}
transmembrane domain {32-52}
cytoplasmic loop {53-67}
transmembrane domain {68-88}
exoplasmic loop {89-101}
transmembrane domain {102-124}
cytoplasmic loop {125-146}
transmembrane domain {147-167}
exoplasmic loop {168-186}
MOTIF: N-glycosylation site {N172}
transmembrane domain {187-207}
cytoplasmic loop {208-240}
transmembrane domain {241-261}
exoplasmic loop {262-276}
transmembrane domain {277-297}
cytoplasmic domain {298-353}
MOTIF: cysteine residue {C309}
MODIFICATION: palmitate
COMPARTMENT: membrane
Database Correlations
OMIM 605106
UniProt Q9UBY5
Pfam PF00001
Kegg hsa:2356
References
UniProt :accession Q9UBY5