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loop diuretic
Indications:
- heart failure
- fluid overload, edema, peripheral edema, pulmonary edema
- markedly decreased renal function. oliguria
- hypertension
- hypercalcemia [4]
* do not change loop diuretic to thiazide diuretic for hyperkalemia in patients with systolic heart failure [5]
Monitor:
- serum electrolytes, serum Mg+, serum Ca+2 annually [3]
Adverse effects:
1) hyperuricemia
2) hypocalcemia
3) hypokalemia
4) ototoxicity
5) rash
6) vasculitis
7) diuretic resistance
Mechanism of action:
- site of action: loop of Henle
- not as effective as thiazide for lowering blood pressure in most patients [2]
Interactions
drug interactions
drug adverse effects (more general classes)
monitor with loop diuretics
Related
diuretic resistance
Specific
bumetanide (Bumex, Enbumyst)
ethacrynic acid (Edecrin)
furosemide (Lasix, Furoscix)
torsemide (Demadex)
General
diuretic
References
- Manual of Medical Therapeutics, 28th ed, Ewald &
McKenzie (eds), Little, Brown & Co, Boston, 1995, pg 123
- Prescriber's Letter 16(2): 2008
Comparison of Commonly Used Diuretics
Detail-Document#: 250214
(subscription needed) http://www.prescribersletter.com
- deprecated reference
- Deprecated Reference
- NEJM Knowledge+