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loop diuretic
Indications:
- heart failure
- fluid overload, edema, peripheral edema, pulmonary edema
- markedly decreased renal function. oliguria
- hypertension
- hypercalcemia [4]
* do not change loop diuretic to thiazide diuretic for hyperkalemia in patients with systolic heart failure [5]
Monitor:
- serum electrolytes, serum Mg+, serum Ca+2 annually [3]
Adverse effects:
1) hyperuricemia
2) hypocalcemia
3) hypokalemia
4) ototoxicity
5) rash
6) vasculitis
7) diuretic resistance
Mechanism of action:
- site of action: loop of Henle
- not as effective as thiazide for lowering blood pressure in most patients [2]
Interactions
drug interactions
drug adverse effects (more general classes)
monitor with loop diuretics
Related
diuretic resistance
Specific
bumetanide (Bumex)
ethacrynic acid (Edecrin)
furosemide (Lasix, Furoscix)
torsemide (Demadex)
General
diuretic
References
- Manual of Medical Therapeutics, 28th ed, Ewald &
McKenzie (eds), Little, Brown & Co, Boston, 1995, pg 123
- Prescriber's Letter 16(2): 2008
Comparison of Commonly Used Diuretics
Detail-Document#: 250214
(subscription needed) http://www.prescribersletter.com
- deprecated reference
- Deprecated Reference
- NEJM Knowledge+