lon protease homolog, mitochondrial; lon protease-like protein; LONP; LONHs; mitochondrial ATP-dependent protease lon; serine protease 15 (LONP1, PRSS15)

Function: - required for intramitochondrial proteolysis - catalyzes initial steps of protein degradation - hydrolyzes ATP & degrades protein & peptide substrates (ATP-dependent) - binds to single-stranded but not to double-stranded DNA Structure: - belongs to the peptidase S16 family - contains 1 lon domain Compartment: mitochondrial matrix Expression: - expressed in duodenum, heart, lung & liver - not expressed in thymus

General

mitochondrial protein serine protease

Properties

SIZE: entity length = 959 aa MW = 106 kD COMPARTMENT: mitochondrial matrix MOTIF: Lon {123-368} ATP-binding site NAME: ATP-binding site SITE: 523-530 serine residue {S855} lysine residue {K898}

Database Correlations

OMIM 605490 UniProt P36776

References

UniProt :accession {P36776 P36777}