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long term depression (LTD)

LTD is an activity-dependent synapse-specific decrease in synaptic efficacy. It is long-lasting, persisting for days to weeks. LTD is a form of neuronal plasticity that may form the basis for forgetting. Ca+2 influx through NMDA receptors is critical for induction of LTD [1]. In contast to LTP, low levels of intracellular Ca+2 are involved in LTD. [2] Dephosphorylation of S845 in GluR1 of AMPA receptors may also play a role. [2]

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forgetting

General

modulation

References

  1. Villarreal et al Nature neurosciences 5:48, 2001
  2. Castellani GC, Quinlan EM, Bersani F, Cooper LN, Shouval HZ. A model of bidirectional synaptic plasticity: From signaling network to channel conductance. Learn Mem. 2005 Jul 18; [Epub ahead of print] PMID: 16027175