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lolamicin

Indications: - bacterial infection with multidrug-resistant gram-negative bacteria - spares the gut microbiome Mechanism of action: - targets lipoprotein transport system - selective bactericidal activity for pathogenic Gram-negative bacteria results from low sequence homology for the target in pathogenic bacteria vs commensals [1]

General

antibacterial agent

References

  1. Munoz KA, Ulrich RJ, Vasan AK et al A Gram-negative-selective antibiotic that spares the gut microbiome. Nature. 2024 May 29 PMID: 38811738 https://www.nature.com/articles/s41586-024-07502-0.epdf