LMP-2/ring-12 protein (proteasome subunit beta type-9, proteasome chain 7, macropain chain 7, multicatalytic endopeptidase complex chain 7, RING12 protein, low molecular mass protein 2, PSMB9, LMP2, RING12)

Function: - component of the 20S proteasome which is a component of the 26S proteasome - PSMB9 is involved in antigen processing to generate MHC class 1 binding peptides - PSMB9 displaces the equivalent houskeeping subunit PSMB6 - a model for self-activation in which residue Thr-21 serves as nucleophile & Lys-53 as proton donor/acceptor has been proposed Structure: belongs to the peptidase T1B family Compartment: cytoplasm (putative), nucleus Alternative splicing: named isoforms=2 Expression: induced by interferon gamma Genetics: encoded in the MHC class 2 region Miscellaneous: A model for self-activation in which residue Thr-21 serves as nucleophile & Lys-53 as proton donor/acceptor has been proposed. subunit processing of mammalian beta-subunits proceeds via a novel ordered two-step mechanism involving autocatalysis

Properties

SIZE: entity length = 219 aa MW = 23 kD COMPARTMENT: cytoplasm cell nucleus

Database Correlations

OMIM 177045 UniProt P28065 Pfam PF00227 Kegg hsa:5698 ENZYME 3.4.25.1

References

UniProt :accession P28065