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liver elastography; hepatic transient elastography (FibroScan)
Indications:
- evaluation of hepatic fibrosis & cirrhosis
- vibration-controlled transient elastography used in combination with age, sex, diabetes status, serum AST, serum ALT & platelet count [3,4,5]
- hepatic transient elastography is used to estimate risk of portal hypertension & need for non-selective beta-blocker prophylaxis for esophageal varices [2]
Procedure:
- ultrasound technique that uses mechanically induced shear wave
Interpretation:
- a threshold of >= 8.0 kPa considered elevated
- a threshold of >= 25 kPa considered need for non-selective beta-blocker prophylaxis for esophageal varices [2]
- a Fibrosis-4 score of 3.03 suggests high risk of advanced cirrhosis
General
elastography
References
- Harris R, Card T, Delahooke T, Aithal GP, Guha IN.
Obesity is the most common risk factor for chronic liver disease:
Results from a risk stratification pathway using transient elastography.
Am J Gastroenterol 2019 Aug 27;
PMID: 31453812
https://insights.ovid.com/crossref?an=00000434-900000000-99567
- NEJM Knowledge+ Gastroenterology
- Lin H et al.
Vibration-controlled transient elastography scores to predict liver-related
events in steatotic liver disease.
JAMA 2024 Mar 21;
PMID: 38512249 PMCID: PMC10958386 (available on 2024-09-21)
https://jamanetwork.com/journals/jama/fullarticle/2816449
- Sanyal AJ et al
Enhanced diagnosis of advanced fibrosis and cirrhosis in individuals with NAFLD
using FibroScan-based Agile scores
J Hepatol. 2023 Feb;78(2):247-259.
PMID: 36375686 PMCID: PMC10170177 Free PMC article.
https://www.journal-of-hepatology.eu/article/S0168-8278(22)03293-7/fulltext
- Pennisi G et al
AGILE 3+ Score for the Diagnosis of Advanced Fibrosis and for Predicting Liver-
related Events in NAFLD.
Clin Gastroenterol Hepatol. 2023 May;21(5):1293-1302.e5.
PMID: 35842119
https://www.cghjournal.org/article/S1542-3565(22)00646-2/abstract