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liver 6-phosphofructokinase; phosphofructokinase 1; phosphohexokinase; phosphofructo-1-kinase isozyme B; PFK-B (PFKL)
Function:
- 6-phosphofructokinase in liver
- carbohydrate degradation, glycolysis
- D-glyceraldehyde 3- phosphate & glycerone phosphate from D-glucose: step 3/4
- allosteric enzyme activated by ADP, AMP, or fructose bisphosphate & inhibited by ATP or citrate
Cofactor: Mg+2
Structure:
- tetramer
- belongs to the phosphofructokinase family, two domains subfamily
Alternative splicing: named isoforms=2
General
6-phosphofructo-1-kinase, phosphohexokinase or phosphofructokinase-1
Properties
SIZE: entity length = 780 aa
MW = 85 kD
COMPARTMENT: cytoplasm
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 35-39
aspartate residue {D166}
ATP-binding site
NAME: ATP-binding site
SITE: 193-197
binding site
SITE: 201-201
FOR-BINDING-OF: Substrate
ATP-binding site
NAME: ATP-binding site
SITE: 210-226
MOTIF: Mg+2-binding site
SITE: 224-224
binding site
SITE: 292-292
FOR-BINDING-OF: Substrate
binding site
SITE: 298-298
FOR-BINDING-OF: Substrate
binding site
SITE: 301-301
FOR-BINDING-OF: Substrate
Tyr phosphorylation site {Y633}
Database Correlations
OMIM 171860
UniProt P17858
ENZYME 2.7.1.11
References
UniProt :accession P17858