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ritlecitinib (Litfulo)
Indications:
- treatment of alopecia areata in adults & adolecents >= 12 years
Contraindications:
- use in combination with other JAK inhibitors, immunosuppressants, cyclosporine, biologic immunmodulators
- rheumatoid arthritis (highe mortality vs TNF-alpha inhibitor)
Dosage:
- 50 mg orally once daily.
Adverse effects:
- venous thromboembolism
- pulmonary embolism
- arterial thromboembolism
- headache, diarrhea, acne, rash, urticaria, folliculitis, pyrexia
- atopic dermatitis, dizziness, increased serum creatine phosphokinase, herpes zoster, anemia, stomatitis
* Warnings:
- serious infection, malignancy, major cardiovascular events, thrombosis, death
Interactions
drug adverse effects of tyrosine kinase inhibitor(s)
General
Janus kinase inhibitor; JAK inhibitor
Database Correlations
PUBCHEM correlations
References
- Highlights of Prescribing Information
ritlecitinib (Litfulo). Capsules.
https://labeling.pfizer.com/ShowLabeling.aspx?id=19638