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lipopolysaccharide-induced tumor necrosis factor-alpha factor (LPS-induced TNF-alpha factor, p53-induced protein 7, small integral membrane protein of lysosome/late endosome, LITAF, PIG7, SIMPLE)
Function:
1) role in regulating transcription of specific genes
a) expression of chemokine CCL2/MCP-1 via NFKB1
b) expression of tumor necrosis factor alpha (TNF-alpha)
2) interacts with NEDD4, WWOX via WW-binding motif
3) isoform 2 may interact with STAT6
4) induced by lipopolysaccharides (LPS) or p53
5) in monocytes induced by Bacillus Calmette-Guerin (BCG)
Compartment:
- lysosomal membrane, plasma membrane (cytoplasmic side)
Alternative splicing: named isoforms=2
Expression:
- ubiquitously & abundantly expressed
- expressed in placenta, peripheral blood leukocytes, lymph nodes, spleen
Pathology:
1) defects associated with Charcot-Marie-Tooth disease type 1C (CMT1C)
2) defects associated with extramammary Paget disease
General
other protein
Properties
SIZE: MW = 17 kD
entity length = 161 aa
COMPARTMENT: lysosome
cytoplasm
Database Correlations
OMIM correlations
MORBIDMAP 603795
UniProt Q99732
References
UniProt :accession Q99732