Lipolysis-stimulated lipoprotein receptor (LSR LISCH)

Function: - probable role in the clearance of triglyceride-rich lipoprotein from blood - binds chylomicrons, LDL & VLDL in presence of free fatty acids & allows their subsequent uptake in cells (putative) Structure: - homotrimer or homotetramer (putative) - belongs to the immunoglobulin superfamily, LISCH7 family - contains 1 Ig-like V-type domain (immunoglobulin-like) Compartment: cell membrane Alternative splicing: named isoforms=3 Comparative biology: - in contrast to the rodent orthologous protein, it is longer in N-terminus & no signal sequence is detected by any prediction method

General

immunoglobulin superfamily protein membrane protein phosphoprotein

Properties

SIZE: MW = 71 kD entity length = 649 aa COMPARTMENT: cellular membrane MOTIF: immunoglobulin superfamily domain {86-234} MOTIF: cysteine residue {C111} MODIFICATION: cysteine residue {C218} cysteine residue {C218} MODIFICATION: cysteine residue {C111} transmembrane domain {260-280} cysteine-rich region {280-304} Ser phosphorylation site {S364} Ser phosphorylation site {S436} Ser phosphorylation site {S493} Ser phosphorylation site {S530} Tyr phosphorylation site {Y535} Ser phosphorylation site {S646}

Database Correlations

UniProt Q86X29 Pfam PF05624

References

UniProt :accession Q86X29