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liposarcoma
Epidemiology: ~20% of adulthood sarcomas [2]
Pathology:
Microscopic pathology:
Identification of lipoblasts which range from:
1) primitive mesenchymal cells with only tiny lipid droplets
2) intermediate form with scanty cytoplasm, multiple variably sized lipid droplets and small nucleus centrally or peripherally located
3) signet-ring like cells with most of cytoplasm occupied by single large fat droplet
Histologic subtypes:
1) well-differentiated liposarcoma (atypical lipoma/atypical lipomatous tumor)
a) lipoma like
b) sclerosing
c) inflammatory
d) spindle cell
e) dedifferentiated
2) myxoid liposarcoma
a) round cell liposarcoma
3) pleomorphic liposarcoma
* histopathology images [4]
Genetics:
- implicated genes PRUNE
Interactions
disease interactions
Specific
dedifferentiated liposarcoma
myxoid liposarcoma
pleomorphic liposarcoma
round cell liposarcoma
well-differentiated liposarcoma; atypical lipomatous tumor; sclerosing liposarcoma; inflammatory liposarcoma; spindle cell liposarcoma
General
adipose tissue neoplasm
soft tissue sarcoma (STS)
References
- Enzinger & Weiss. Soft Tissue Tumors.
Mosby. 3rd ed. 1995
- Gebhard et al. Am J Surgical Pathology 26:601-16, 2002
- DermNet NZ. Lipoma and liposarcoma (images)
http://www.dermnetnz.org/lesions/lipoma.html
- DermNet NZ. Liposarcoma pathology (histopathology images)
http://www.dermnetnz.org/pathology/liposarcoma-path.html
- Schwartz RA, Elston DM (CT image)
Medscape: Liposarcoma
http://emedicine.medscape.com/article/1102007-overview