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lipoprotein ; Lp

Function: - Lp inhibits activation of plasminogen, thus inhibits fibrinolytic activity Structure: - very similar to LDL except that its apoB100 is covalently attached via disulfide linkage to apo, a large MW protein [400-800 kD] with homology to plasminogen Expression: - synthesized in the liver Pharmacology: - olpasiran is a small interfering RNA that reduces lipoprotein(a) synthesis in the liver [6]

Related

lipoprotein in serum

General

lipoprotein macromolecular complex

Properties

COMPARTMENT: membrane

References

  1. Grainger et al Science 260:1655 1993
  2. Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998
  3. Tietz Textbook of Clinical Chemistry, 2nd ed. Burtis CA & Ashwood ER (eds), WB Saunders Co, Philadelphia PA, 1993, pg 1023-24
  4. Suk Danik J et al, Lipoprotein(a), measured with an assay independent of apolipoprotein(a) isoform size, and risk of future cardiovascular events among initially healthy women. JAMA 2006, 296:1363 PMID: 16985228
  5. Bennet A, Di Angelantonio E, Erqou S, Eiriksdottir G, et al, Lipoprotein(a) Levels and Risk of Future Coronary Heart Disease: Large-Scale Prospective Data. Arch Intern Med. 2008 Mar 24;168(6):598-608. PMID: 18362252
  6. O'Donoghue ML, Rosenson RS, Gencer B et al Small Interfering RNA to Reduce Lipoprotein(a) in Cardiovascular Disease. N Engl J Med. 2022. Nov 6 PMID: 36342163 https://www.nejm.org/doi/full/10.1056/NEJMoa2211023
  7. Wikipedia: Lipoprotein(a) http://en.wikipedia.org/wiki/Lipoprotein(a)

Components

apolipoprotein apolipoprotein B100 (apoB100) cholesterol cholesterol ester phosphatidylcholine (lecithin) triglyceride