Search
lipophilic statin
Indications:
- may confer a survival advantage across different histologic sybtypes of ovarian cancer
Adverse effects:
- discontinuation of lipophilic statin* increases risk of Parkinson's disease [1]
* lipophilic statins cross the blood brain barrier
Interactions
drug interactions
drug adverse effects (more general classes)
monitor with HMG CoA reductase inhibitors (statins)
Specific
atorvastatin (Lipitor)
cerivastatin; rivastatin (Baycol, Lipobay)
lovastatin (Mevacor, Altocor, monacolin-K, Altoprev)
mevastatin
pitavastatin; nisvastatin; itavastatin (Livalo)
simvastatin (Zocor)
General
HMG CoA reductase inhibitor (statin)
Properties
INHIBITS: HMG CoA reductase
References
- Physician's First Watch, July 25, 2013
David G. Fairchild, MD, MPH, Editor-in-Chief
Massachusetts Medical Society
http://www.jwatch.org
- Lee Y-C et al.
Discontinuation of statin therapy associates with Parkinson
disease: A population
PMID: 23884037
http://neurology.org/content/early/2013/07/24/WNL.0b013e31829d873c
- Ingram I
Yet Another Reason to Take Statins?
- Retrospective study showed 40% reduction in mortality for
ovarian cancer patients.
MedPage Today June 23, 2020
https://www.medpagetoday.com/meetingcoverage/aacr/87219
- Visvanathan K, et al
Lipophilic statins show promise for treatment of epithelial
ovarian cancer.
American Association for Cancer Research (AACR) 2020; Abstract 5782.