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liprin-alpha-1; LAR-interacting protein 1; LIP-1; protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1; PTPRF-interacting protein alpha-1 (PPFIA1, LIP1)
Function:
- may regulate disassembly of focal adhesions
- may localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment & their association with substrates
- phosphorylated upon DNA damage, probably by ATM or ATR
- forms homodimers & heterodimers with liprins-alpha & liprins-beta
- interacts with the second PTPase domain of PTPRD, PTPRF & PTPRS
- interacts with GIT1, KIF1A & GRIP1
Structure:
- the N-terminal coiled coil regions mediate homodimerization preferentially & heterodimerization type alpha/alpha
- the C-terminal, non-coiled coil regions mediate heterodimerization type alpha/beta & interaction with PTPRD, PTPRF & PTPRS
- belongs to the liprin family, liprin-alpha subfamily
- contains 3 SAM (sterile alpha motif) domains
Compartment:
- cytoplasm
- colocalizes with PTPRF at the ends of focal adhesions most proximal to the cell nucleus
Alternative splicing:
- named isoforms=2
- intron retention
Expression: ubiquitous
Related
receptor-type tyrosine-protein phosphatase F; Leukocyte common antigen related; LAR (PTPRF, LAR)
General
liprin-alpha (protein tyrosine phosphatase receptor type F polypeptide-interacting protein alpha, PTPRF-interacting protein alpha)
Properties
SIZE: entity length = 1202 aa
MW = 136 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: glycine-rich region {17-25}
coiled coil {34-141}
coiled coil {176-214}
Thr phosphorylation site {T230}
Ser phosphorylation site {S239}
Ser phosphorylation site {S242}
Ser phosphorylation site {S244}
coiled coil {249-521}
coiled coil {623-669}
MOTIF: Ser phosphorylation site {S668}
Tyr phosphorylation site {Y684}
Ser phosphorylation site {S693}
Ser phosphorylation site {S741}
Ser phosphorylation site {S745}
Ser phosphorylation site {S763}
Ser phosphorylation site {S776}
coiled coil {847-871}
sterile alpha motif
NAME: sterile alpha motif
SITE: 878-944
sterile alpha motif
NAME: sterile alpha motif
SITE: 963-1027
coiled coil {1021-1050}
SAM 3 {1051-1120}
Thr phosphorylation site {T1159}
Ser phosphorylation site {S1172}
Database Correlations
OMIM 611054
UniProt Q13136
PFAM correlations
Entrez Gene 8500
Kegg hsa:8500
References
UniProt :accession Q13136