Search
LIM & senescent cell antigen-like-containing domain protein 2 (particularly interesting new Cys-His protein 2, PINCH-2, LIM-like protein 2, LIMS2, PINCH2)
Function:
1) competes with LIMS1 for binding to ILK
2) modulates cell spreading & migration
3) interacts with ILK
4) component of complex with ILK & PARVA
Compartment: nucleus, cell junction, adhesion, cytoplasmic side
Alternative splicing: named isoforms=3
General
LIM & senescent cell antigen-like-containing domain protein (particularly interesting new Cys-His protein, LIMS)
Properties
SIZE: MW = 39 kD
entity length = 341 aa
COMPARTMENT: cytoplasm
MOTIF: LIM domain {13-74}
MOTIF: cysteine residue (6)
histidine residue
Zn+2-binding site
LIM domain {76-133}
MOTIF: cysteine residue (6)
histidine residue
Zn+2-binding site
LIM domain {138-195}
MOTIF: cysteine residue (6)
histidine residue
Zn+2-binding site
LIM domain {196-255}
MOTIF: cysteine residue (6)
histidine residue
Zn+2-binding site
LIM domain {256-315}
MOTIF: cysteine residue (6)
histidine residue
Zn+2-binding site
Database Correlations
OMIM 607908
UniProt Q7Z4I7
Pfam PF00412
References
UniProt :accession Q7Z4I7