LIM & senescent cell antigen-like-containing domain protein 1 (particularly interesting new Cys-His protein 1, PINCH-1, NY-REN-48 antigen, LIMS1, PINCH, PINCH1)

Function: 1) effector of integrin & growth factor signaling 2) couples surface receptors to downstream signaling molecules 3) regulation of cell survival, cell proliferation, cell differentiation 4) focal adhesion protein 5) component of complex ILK-PINCH 6) interacts ILK, NCK2 Compartment: cell junction, focal adhesion, cytoplasmic side Expression: expressed in most tissues, except in the brain

Properties

SIZE: MW = 37 kD entity length = 324 aa COMPARTMENT: cytoplasm MOTIF: acetylation site SITE: 1-1 EFFECTOR-BOUND: acetyl LIM domain {9-61} MOTIF: cysteine residue (6) histidine residue Zn+2-binding site LIM domain {70-120} MOTIF: cysteine residue (6) histidine residue Zn+2-binding site LIM domain {134-183} MOTIF: cysteine residue (6) histidine residue Zn+2-binding site LIM domain {192-242} MOTIF: cysteine residue (6) histidine residue Zn+2-binding site LIM domain {251-302} MOTIF: cysteine residue (6) histidine residue Zn+2-binding site

Database Correlations

OMIM 602567 UniProt P48059 Pfam PF00412

References

UniProt :accession P48059