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LIM domain-containing protein 2 (LIMD2)
Function:
- bound directly to the kinase domain of integrin-linked kinase (ILK) near the active site, strongly activated ILK kinase activity
Structure: contains 1 LIM Zn+2-binding domain
Expression: overexpressed in metastatic lesions but absent in the matched primary tumor
Pathology:
- may play a role in metastasis via activation of ILK
General
other protein
Properties
SIZE: MW = 14 kD
entity length = 127 aa
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
LIM domain {38-98}
MOTIF: cysteine residue (6)
histidine residue
Zn+2-binding site
Database Correlations
UniProt Q9BT23
Pfam PF00412
Entrez Gene 80774
Kegg hsa:80774
References
- UniProt :accession Q9BT23
- Peng H et al
LIMD2 Is a Small LIM-Only Protein Overexpressed in Metastatic
Lesions That Regulates Cell Motility and Tumor Progression by
Directly Binding to and Activating the Integrin-Linked Kinase.
Cancer Res March 1, 2014 74; 1390
PMID: 24590809
http://cancerres.aacrjournals.org/content/74/5/1390.abstract